Constanza Paulina Silva Gallardo

Constanza Paulina Silva Gallardo

Ph.D. Candidate at Biobehavioral Health

The Pennsylvania State University

Biography

English version:

Constanza Paulina Silva Gallardo is a Ph.D. Candidate in the Department of Biobehavioral Health and predoctoral fellow at the Prevention and Methodology Center at The Pennsylvania State University. She is interested in the behavioral genomics of tobacco and alcohol use in mouse models and humans. Her past research has focused on nicotine exposure during adolescence and its effects on alcohol consumption and gene expression. She is currently studying: (1) the impact of reduced nicotine-content cigarettes (Spectrum) and their impact on genomic marks, craving, and withdrawal relief; and (2) looking at the association between adolescent cigarette smoking and marijuana use over time utilizing time-varying effect modeling (TVEM). These interdisciplinary approaches have the aim of addressing the complexities of nicotine addiction and substance use. Constanza has experience as a laboratory technician, in genomic data analysis, and teaching. Additionally, she has writing and communication skills in both Spanish and English.

Versión en Español:

Constanza Paulina Silva Gallardo es candidata a doctora en el departamento de Salud Bioconductual y becaria predoctoral en el Centro de Prevención y Metodología de la Universidad Estatal de Pennsylvania. Está interesada en las marcas genomicas y el comportamiento asociado al uso de tabaco y alcohol en modelos animales y humanos. Sus investigaciones anteriores han estado enfocadas en los efectos de la exposición a la nicotina durante la adolescencia y los efectos de ésta en el consumo de alcohol y expresión génica en el cerebro. Actualmente está estudiando: (1) el impacto de los cigarrillos con nicotina reducida (Spectrum) y su impacto en las marcas genómicas, el alivio de los síntomas de abstinencia; y (2) la asociación entre el inicio en el consumo de cigarrillos y la frecuencia del consumo de marihuana en adolescentes a lo largo del tiempo, utilizando time-varying effect modeling (TVEM). Estos enfoques interdisciplinarios tienen el objetivo de abordar las complejidades de la adicción a la nicotina y el uso de sustancias adictivas. Constanza tiene experiencia como técnica de laboratorio, en el análisis de datos genómicos, y en docencia. Además, tiene habilidades de escritura y comunicación tanto en español como en inglés.

Interests

  • Nicotine exposure during adolescence
  • Reduced Nicotine-Content (RNC) Cigarettes
  • Nicotine and Alcohol co-use
  • Nicotine and Cannabis co-use
  • Prevention Science
  • Genomics

Education

  • Biobehavioral Health Ph.D. Candidate (All but dissertation), 2021

    Department of Biobehavioral Health, College of Health and Human Development, The Pennsylvania State University

  • Extension Certificate in Linguistics and Indigenous Cultures, 2020

    College of Social Sciences, University of Chile, Santiago, Chile

  • MS. in Biobehavioral Health, 2018

    Department of Biobehavioral Health, College of Health and Human Development, The Pennsylvania State University

  • Graduate Certificate in Applied Bioinformatics, 2018

    Department of Biochemistry and Molecular Biology, Eberly College of Science, The Pennsylvania State University

  • BSc in Biological Anthropology, 2014

    Department of Anthropology, College of Social Sciences, University of Chile, Santiago, Chile

Fellowships and Training Grants

The Prevention and Methodology Training Program (PAMT; T32 DA017629)

The Prevention and Methodology Training Program (PAMT; T32 DA017629) has been funded by the National Institute on Drug Abuse (NIDA) since 2005. PAMT makes a unique contribution to the nation’s training of prevention scientists and to the NIDA portfolio by fostering careers that focus on integrating drug abuse/HIV prevention science and innovative methodology.

Biomedical Big Data to Knowledge Training Grant (B2D2K; T32 LM012415)

This NIH-sponsored Training Program comprises a diverse cohort of next-generation scientists engaged in integrative analyses of biomedical data to advance science and improve health. Students learn to develop novel algorithmic and statistical methods with which to build predictive, explanatory, and causal models for integrative analysis of electronic health records and genomics, behavioral, socio-economic, and environmental data to advance science and improve health. Trainees are supported for a period of two years as a part of their doctoral program.

BECAS CHILE- Chilean scholarship for international Ph.D. degrees (N° 72160326)

Competitive scholarship for Chilean students pursuing Ph.D. degrees abroad.

Projects

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Nicotine during adolescence alters ethanol intake and gene expression

Associations between nicotine smoking initiation and cannabis use in adolescence

Population estimation using Identity by Descent (IBD): Application of network theory on population genetics

Using Identity by Descent (IBD) to identify populations and their relationships using network theory

Reduced nicotine content (RNC) cigarettes

Pharmacokinetic profile of Spectrum reduced nicotine cigarettes

Reduced-nicotine content (RNC) cigarettes and gene expression

Reduced-nicotine content cigarette effects on gene expression associated to craving and withdrawal symptoms among heavy smokers

Time-varying effect modeling for cigarette smoking initiation and marijuana use in adolescents

Associations between nicotine smoking initiation and cannabis use in adolescence

Skills

R

Statistics

Data Analysis

Laboratory

English/Spanish

Contact

  • 432 Human and Health Development (HHD), The Pennsylvania State University, University Park, PA 16802
  • Enter Building 1 and take the stairs to Office 200 on Floor 2
  • DM Me